Quantifying glioma cell growth and invasion in vitro

A mathematical model has been developed to describe and quantify the growth and invasion of gliomas (the most common type of primary brain tumors). The model has already been shown to agree well with in vivo imaging studies of gliomas. Here we demonstrate the model’s agreement with in vitro experimental data. The analysis provided in this article demonstrates that the model agrees well with published observations of growth and invasion of gliomas cells in culture. These in vitro results support the model’s utility in describing the behavior of glioma cells in experimental settings but also lends credence to the applications of the model to the in vivo setting. c © 2007 Elsevier Ltd. All rights reserved.